I have heard this question a bit recently. I am a little surprised that people are still only just starting to look at VS2005, but I digress already. There isn't a simple answer to this other than to say that, yes, there are changes and you will have to learn new stuff.
I think most people aren't thinking ahead when they ask this question. What happens when Orcas comes out? I think that making a jump from VS2003 (or earlier) to Orcas is really going to hurt. Developers would benefit from getting on to VS2005 as soon as possible to make the migration to Orcas less painful.
Just a thought...
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